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Doppeldata - Adelaide Bioinformatics

Bioinformatics, statistical genomics & computational biology - practical tools, learning resources, and expert guidance based in South Australia. We are a community that believes in accessible knowledge and learning together.

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© 2026 Doppeldata. All rights reserved. Proudly supporting Adelaide's research community 🇦🇺 ABN: 36 122 512 567 · Built with Quarto

Continuous Variant Reinterpretation Workflow

Clinical Health

Built a workflow to automatically re-evaluate previously sequenced variants as new evidence emerges, surfacing cases whose classification has changed.

GWAS & Colocalisation for Splice-Switching Oligonucleotide Targets

Identified shared causal variants between disease and sQTL signals to support therapeutic candidate selection for a splicing-focused biotech client.

Spatial Epidemiology & Disease Hotspot Mapping

SA2-level cluster detection and geographic accessibility modelling to support regional and rural health service planning.

Health Equity & Socioeconomic Gradient Analysis

SEIFA-linked modelling of health outcome disparities across metro and regional South Australia to inform equity-focused program design.

Population Health Trend Dashboard

Population Health

Chronic disease prevalence tracking by region and demographic, built to support policy and resourcing decisions across South Australia.

Whole Genome Sequencing Variant Interpretation Workflow

Built an annotation, filtering, and clinical significance tiering pipeline for WGS results delivered through the Doppeldata kit program.

Variant Annotation & ACMG Classification Workflow

Clinical Health

Reproducible variant annotation and ACMG-guided classification workflow to support clinical interpretation of sequencing results.

Microbiome Diversity & Composition Analysis

16S microbiome analysis covering alpha/beta diversity, taxonomic composition, and differential abundance across sample groups for a microbiome study.

RNA-seq Differential Expression Analysis

End-to-end RNA-seq differential expression pipeline with QC, normalisation, and pathway enrichment for a research group comparing treatment conditions.